NFL Week 1 Odds, Picks, and Predictions

The Dallas Cowboys and Tampa Bay Buccaneers kicked off the 2021-22 NFL season on Thursday night. The defending Super Bowl champs walked away with a 31-29 victory over Dak Prescott’s Cowboys. Dallas and Tampa Bay both set the bar high for the rest of the NFL.

With the 2021-22 season in full swing, here’s a quick look at all the betting odds for the Week 1 Sunday games.

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2021-22 NFL Week 1 Betting odds Early Games

Philadelphia Eagles vs. Atlanta Falcons

Spread: Atlanta Falcons (-3.0), Philadelphia Eagles (+3.0)

Money Line: Atlanta Falcons (-175), Atlanta Falcons (+150)

Over-Under: 49

The new-look Atlanta Falcons are entering their first game without star wide receiver Julio Jones against the Eagles. Jalen Hurts finally receives the nod to be the franchise quarterback for the Eagles. Atlanta and Philadelphia are both pegged to be on the outside of the playoffs in 2021.

Prediction: Atlanta Falcons 34, Philadelphia Eagles 21

Pittsburgh Steelers vs. Buffalo Bills

Spread: Buffalo Bills (-6.5), Pittsburgh Steelers (+6.5)

Money Line: Buffalo Bills (-290), Pittsburgh Steelers (+235)

Over-Under: 48

Ben Roethlisberger will lead the Pittsburgh Steelers for the last time in 2021. Josh Allen and the Buffalo Bills have a goal of making the Super Bowl. Pittsburgh and Buffalo both have the talent to compete in the AFC in 2021.

Prediction: Buffalo Bills 35, Pittsburgh Steelers 24

Minnesota Vikings vs. Cincinnati Bengals

Spread: Minnesota Vikings (-3), Cincinnati Bengals (+3)

Money Line: Minnesota Vikings (-160), Cincinnati Bengals (+140)

Over-Under: 47

The Cincinnati Bengals fan base has waited patiently for the Joe Burrow-Ja’Marr Chase duo to appear on the field together. Kirk Cousins is entering an interesting season with the Vikings. Cousins must perform, or the Vikings will start to look for his replacement.

Predictions: Minnesota Vikings 24, Cincinnati Bengals 10

San Francisco 49ers vs. Detroit Lions

Spread: San Francisco 49ers (-8.5), Detroit Lions (+8.5)

Money Line: San Francisco 49ers (-430), Detroit Lions (+330)

Over-Under: 46

Jimmy Garoppolo and the 49ers are looking to remain healthy in 2021. The Detroit Lions may be the most underrated team in the NFL. Jared Goff is a proven winner, but he’ll need help from the Lions’ defense to make a run at the playoffs this season.

Predictions: San Francisco 49ers 28, Detroit Lions 17

Arizona Cardinals vs. Tennessee Titans

Spread: Tennessee Titans (-3), Arizona Cardinals (+3)

Money Line: Tennessee Titans (-150), Arizona Cardinals (+130)

Over-Under: 53.3

Tennessee may be a dark horse in the AFC to compete with the Kansas City Chiefs. The Titans added former Falcons star wideout Julio Jones to join Derrick Henry and AJ Brown. Kyler Murray and the Arizona Cardinals also added talent this offseason. Sunday’s game looks to be heading in the direction of a shootout.

Predictions: Arizona Cardinals 42, Tennessee Titans 35

Seattle Seahawks vs. Indianapolis Colts

Spread: Seattle Seahawks (-3), Indianapolis Colts (+3)

Money Line: Seattle Seahawks (-160), Indianapolis Colts (+140)

Over-Under: 49

The injury-plagued Indianapolis Colts welcome the Seattle Seahawks to kick off their season. Russell Wilson and company are looking to make a big push towards the Super Bowl in 2021. All eyes will be on the Colts in Week 1.

Prediction: Seattle Seahawks 24, Indianapolis Colts 10

Los Angeles Chargers vs. Washington Football Team

Spread: Washington Football Team (-2), Los Angeles Chargers (+2)

Money Line: Washington Football Team (-130), Los Angeles Chargers (+110)

Over-Under: 45

The Washington Football Team begins the Ryan Fitzmagic era on Sunday. The Los Angeles Chargers’ quarterback Justin Herbert will build off his massive 2020 season against Washington. Unfortunately, Washington will be without newly added wideout Curtis Samuels.

Prediction: Los Angeles Chargers 21, Washington Football Team 17

New York Jets vs. Carolina Panthers

Spread: Carolina Panthers (-3.5), New York Jets (+3.5)

Money Line: Carolina Panthers (-200), New York Jets (+170)

Over-Under: 45

Sam Darnold will go head-to-head against his replacement in New York, Zach Wilson. The Jets are still riding the momentum from Wilson’s impressive preseason. Darnold will come into his Week 1 matchup with a lot to prove on Sunday.

Prediction: Carolina Panthers 17, New York Jets 14

Jacksonville Jaguars vs. Houston Texans

Spread: Jacksonville Jaguars (-3), Houston Texans (+3)

Money Line: Jacksonville Jaguars (-170), Houston Texans (+145)

Over-Under: 45.5

Urban Meyer and Trevor Lawrence are both making their regular-season debuts. The Houston Texans are entering Week 1 with Tyrod Taylor at quarterback. Jacksonville will look to get their new beginning off on the right foot against the Texans.

Predictions: Jacksonville Jaguars 34, Houston Texans 17

2021-22 NFL Week 1 Betting odds Late Games

Cleveland Browns vs. Kansas City Chiefs

Spread: Kansas City Chiefs (-5.5), Cleveland Browns (+5.5)

Money Line: Kansas City Chiefs (-240), Cleveland Browns (+200)

Over-Under: 54.5

The Kansas City Chiefs begin their path to redemptions against the Cleveland Browns on Sunday. Sunday’s game will be a rematch from the AFC Divisional Round Playoffs from last season. Kansas City and Cleveland are both projected playoff teams.

Prediction: Kansas City Chiefs 24, Cleveland Browns 21

Miami Dolphins vs. New England Patriots

Spread: New England Patriots (-3), Miami Dolphins (+3)

Money Line: New England Patriots (-180), Miami Dolphins (+155)

Over-Under: 43.5

The Mac Jones era has begun in New England. Tua Tagovailoa and Mac Jones are former teammates at Alabama and now their bitter rivals. Miami and New England both are looking to get off on the right foot Sunday.

Green Bay Packers vs. New Orleans Saints

Spread: Green Bay Packers (-3.5), New Orleans Saints (+3.5)

Money Line: Green Bay Packers (-190), New Orleans Saints (+160)

Over-Under: 49.5

Aaron Rodgers enters his last season as the Green Bay Packers quarterback. Jameis Winston is taking over for future Hall of Fame quarterback Drew Brees. Sunday’s game is FOX Sports game of the week and will not disappoint.

Prediction: Green Bay Packers 24, New Orleans Saints 21

Denver Broncos vs. New York Giants

Spread: Denver Broncos (-3), New York Giants (+3)

Money Line: Denver Broncos (-160), New York Giants (+140)

Over-Under: 41.5

Daniel Jones and the New York Giants will be without tight end Evan Engram on Sunday. The Broncos will start Teddy Bridgewater instead of Drew Lock. With Daniel Jones entering the season on the hot seat. The Giants have a lot to prove this season, and it starts in Week 1.

Prediction: New York Giants 28, Denver Broncos 10

2021-22 NFL Week 1 Betting Odds Sunday and Monday Night Games

Chicago Bears vs. Los Angeles Rams

Spread: Los Angeles Rams (-8), Chicago Bears (+8)

Money Line: Los Angeles Rams (-400), Chicago Bears (+310)

Over-Under: 46.5

The Chicago Bears and Los Angeles Rams both have new faces behind center. Matthew Stafford has been pegged as the savior in Los Angeles. Andy Dalton is likely on a short leash after rookie quarterback Justin Fields put on a massive performance during the preseason.

Prediction: Los Angeles Rams 35, Chicago Bears 17

Baltimore Ravens vs. Las Vegas Raiders

Spread: Baltimore Ravens (-4), Las Vegas Raiders (+4)

Money Line: Baltimore Ravens (-200), Las Vegas Raiders (+170)

Over-Under: 50.5

The Baltimore Ravens are battling the injury bug entering the 2021-22 NFL season. Derek Carr and the Las Vegas Raiders are entering the season with hopes of making a playoff run. Lamar Jackson and company have an uphill climb after suffering injuries to JK Dobbins, Gus Edwards, and Marcus Peters.

Prediction: Las Vegas Raiders 17, Baltimore Ravens 14